Blog
Immune reactivities to peanut proteins, agglutinins, and oleosins
Context: Certain individuals are sensitive enough to react to peanuts and peanut oil, sometimes with deadly effect. It is thus crucial to have an accurate testing methodology for the assessment of allergies and immune reactivities to peanuts and their components, such...
Molecular mimicry as a mechanism for food immune reactivities and autoimmunity
The mucosal immune system is constantly exposed to challenges from the antigenic substances found in food and released from the body's own microbial flora. The body's normal tolerance to friendly antigenic substances can be disrupted by a number of factors, such as...
Metabolic diseases driven by immunoinflammation
Inflammation is normally a protective response that is part of the immune system's reaction to infection. Chronic inflammation, on the other hand, is a sign that there is a breakdown in the immune response system, and leads to chronic inflammatory diseases. More and...
Correlation between antibodies to bisphenol A, its target enzyme protein disulfide isomerase and antibodies to neuron-specific antigens
Evidence continues to increase linking autoimmunity and other complex diseases to the chemicals commonly found in our environment. Bisphenol A (BPA) is a synthetic monomer used widely in many forms, from food containers to toys, medical products and many others. The...
The Gut-Brain Axis: Autoimmune and Neuroimmune Disorders
The human body is an incredibly complex system, and from time immemorial, humans have struggled to work out what the gut and brain have to do with health and whether the 2 are connected. The parallels between the gut’s and the brain’s immune systems are too...
Gluten and Non-Gluten Proteins of Wheat as Target Antigens in Autism, Crohn’s and Celiac Disease
Studies show that patients with celiac disease react not only with gluten wheat proteins but also with non-gluten wheat components. Our goal was to measure IgG or IgA antibodies against wheat proteins or peptides that would provide the most sensitive method for the...
Detection of Islet Cell Immune Reactivity with Low Glycemic Index Foods: Is This a Concern for Type 1 Diabetes?
Dietary management of autoimmune diabetes includes low glycemic foods classified from the glycemic index, but it does not consider the role that immunoreactive foods may play with the immunological etiology of the disease. We measured the reactivity of either...
Immunological Reactivity Using Monoclonal and Polyclonal Antibodies of Autoimmune Thyroid Target Sites with Dietary Proteins
Many hypothyroid and autoimmune thyroid patients experience reactions with specific foods. Additionally, food interactions may play a role in a subset of individuals who have difficulty finding a suitable thyroid hormone dosage. Our study was designed to investigate...
Clinical & Cellular Immunology Correlation of Tissue Antibodies and Food Immune Reactivity in Randomly Selected Patient Specimens
Objectives: Specific food antigens, such as gliadins and caseins, have been well documented as triggering immune reactivity to human tissues, due to cross-reactivity or molecular mimicry. Food antigens, such as agglutinins, are known to bind to human tissues, which...
Blood-based markers in autism spectrum disorders
A definitive test that is universally accepted for accurately diagnosing Autism Spectrum Disorders (ASD) has yet to be developed. Because ASD results from a combination of genetic susceptibility and environmental factors such as infections, dietary proteins,...