During the last several years, there has been growing clinical and scientific evidence that most children with autism suffer from mercury/metal toxicity. Furthermore, there have been many reports from physicians and parents that removal of mercury and other toxic metals can be very beneficial to children with autism, sometimes resulting in a major decrease in autistic symptoms. A wide variety of detoxifying agents and protocols have been used, and the purpose of this paper is to discuss the pros and cons of the different treatments available. Overall, our consensus position is that removal of mercury and other toxic metals is one of the most beneficial treatments for autism and related disorders. More research is needed, but effective treatments are available now. Each child is an individual, so this report presents general guidelines rather than specific recommendations.